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Publications Digest

16
Apr 2025

Sustainability Publication Digest: Greenhouse gas emissions due to inhalation anaesthetics in the Netherlands, usage data and a survey of preferences among Dutch anaesthesiologists

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Friedericy et al. assessed the environmental footprint of inhalation anaesthetics in Dutch hospitals and surveyed anaesthesiologists on practice patterns. A comprehensive 2019 bottom-up evaluation of anaesthetic agent procurement across the Netherlands was conducted. The analysis revealed relatively low greenhouse gas emissions, largely due to the widespread preference for intravenous anaesthesia and the limited use of inhalation-based techniques.
15
Apr 2025

Publication Digest: Death of the P Value? Bayesian Statistics for Orthopedic Surgeons

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. In a recent publication, Polmear et al. examined the growing application of Bayesian statistical methods in orthopedic research, highlighting their advantages over traditional P value-based approaches. The authors emphasized how Bayesian analysis can offer more nuanced interpretations in clinical contexts. Through practical examples ‒ such as diagnostic decision-making in prosthetic joint infection and comparative analysis from the orthopedic trial ‒ the review illustrated key Bayesian concepts and offered guidance for critically evaluating such studies.
14
Apr 2025

EU HTA Publication Digest: Implementation of the EU's Health Technology Assessment regulation: where does existing methods guidance require concretization and what are the relevant methodological options?

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its EU HTA Publications Digest. In a recent publication, Goetz et al. examined where EUnetHTA guidance documents require further methodological clarity in light of the upcoming EU HTA regulation. Through a systematic document review and structured stakeholder discussions conducted in Austria, the authors identified 32 key areas in need of refinement ‒ primarily related to evidence synthesis and eligibility criteria. Drawing on established HTA and evidence synthesis handbooks, the authors proposed concrete methodological options, offering actionable insights to support implementation across EU member states.
10
Apr 2025

Sustainability Publication Digest: Environmental sustainability in dermatological surgery. Part 2: reducing activity and future ecological strategies

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Ali et al. explored practical strategies to reduce the ecological impact of dermatological surgery in the UK, aligning with the National Health Service's commitment to sustainability. The review outlined key system-wide approaches, including reducing overall surgical activity through prevention, promoting research and innovation, and enhancing service management. The authors also highlighted the critical role of managerial policy, procurement practices, and supply chain dynamics in supporting broader national and international sustainability goals.
09
Apr 2025

Health Economic Publication Digest: Development of an instrument (Cost-IS) to estimate costs of implementation strategies for digital health solutions: a modified e-Delphi study

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Donovan et al. introduced Cost-IS, a novel tool designed to support the economic evaluation of implementation strategies for digital health solutions. Its development followed a structured, multi-phase approach involving a literature review, expert interviews, and a modified e-Delphi process. A panel of 12 multidisciplinary experts reached a consensus on the instrument’s core design, though additional piloting is required to evaluate its real-world feasibility and generalizability.
08
Apr 2025

Publication Digest: Food for thought: more explicit guidance for inclusion of caregiver perspectives in health technology assessment

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. In a recent publication, Bourke et al. proposed a novel conceptual framework to support Health Technology Assessment (HTA) processes in reflecting the real-world burden on caregivers. Addressing the current gap in HTA practices caused by limited methodological guidance, the authors offer a structured approach to capture caregiving intensity and duration. Their recommendations aim to assist policymakers, researchers, and manufacturers in aligning HTA submissions with a broader societal perspective.
07
Apr 2025

EU HTA Publication Digest: The EU Health Technology Assessment Regulation Halo Effect: Are Cross-Functional Teams Ready?

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its EU HTA Publications Digest. In a recent publication, Tanner et al. examined key cross-functional challenges stemming from Joint Scientific Consultations (JSC) and Joint Clinical Assessments (JCA) and how manufacturers should address them in their EU HTAR readiness plans. Conducted through literature review, guidance analysis, and manufacturer insights, the study identified five key cross-functional areas: global asset strategy, non-EU regional readiness, launch sequence evolution, brand perception, and pricing impacts. Given the central role of market access in bringing innovation to patients, the EU HTAR will have far-reaching implications, with early Joint Clinical Assessment reports expected to significantly influence brand strategy, pricing dynamics, and global launch sequencing.
03
Apr 2025

Sustainability Publication Digest: Environmental sustainability in dermatological surgery. Part 1: reducing carbon intensity

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Ali et al. explored practical strategies to reduce the carbon footprint of dermatological surgery in the UK, aligning with the National Health Service's commitment to sustainability. The review outlined systemic measures such as sourcing from local suppliers to cut transport-related emissions, implementing streamlined care pathways, and promoting responsible prescribing. It also emphasized the integration of environmental principles into surgical education and the optimization of resource use for consumables, equipment, and energy.
02
Apr 2025

Health Economic Publication Digest: Economic evaluations of medical devices in pediatrics: a systematic review and a quality appraisal of the literature

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Mascarenhas et al. analyzed the landscape of economic evaluations for medical devices in pediatrics, critically appraising their methodological rigor. The systematic literature review identified 39 economic evaluations, with a focus on high-risk therapeutic devices mostly studied in high-income countries. The analysis showed a predominant use of cost-utility analysis and considerable variation in adherence to CHEERS 2022 reporting standards. The findings highlight the need to improve reporting quality and develop methods that reflect the unique health needs of children, including outcome measures meaningful to pediatric patients and their families.
01
Apr 2025

Publication Digest: Methodological expectations for demonstration of health product effectiveness by observational studies

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. In a recent publication, Cucherat et al. proposed formalized methodological criteria for observational studies to serve as credible evidence for health product effectiveness, comparable to randomized controlled trials. Developed through a French expert roundtable, the framework emphasizes predefined protocols and statistical analysis plans, robust causal inference, and minimization of bias. The results offer a structured approach to support regulatory decisions and guideline development.
31
Mar 2025

EU HTA Publication Digest: What is needed to successfully implement the EU HTA Regulation enabling broad patient access in Europe

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its EU HTA Publications Digest. In a recent publication, Lipska et al. explored the policy challenges surrounding the implementation of the EU HTA Regulation, drawing from the discussions of a high-level expert group convened in Rome. The authors proposed actionable recommendations to facilitate the effective launch of the Joint Clinical Assessment framework. Their key insights stress the need for transparent communication, stakeholder engagement, and equitable commitment from all member states to reduce access delays across Europe.
27
Mar 2025

Sustainability Publication Digest: How to choose between single-use and reusable medical materials for sustainable nursing: Methodological lessons learned from a national study

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Vanderwee et al. introduced a pragmatic decision-making approach for healthcare facilities with tools to select environmentally sustainable alternatives to replace single-use options. A cross-sectional multi-center survey in Belgian hospitals was performed, followed by an exploratory analysis of the sustainability of commonly used healthcare materials. The authors developed a structured assessment method, combining real-world procurement data and literature-based evaluations to inform sustainable, safe, and cost-effective material choices.