Publication Digest: Defining Biological and Clinical Plausibility: The DICSA Framework for Protocolized Assessment in Survival Extrapolations Across Therapeutic Areas

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Thöne et al. performed a comparative life-cycle assessment of single-use and reusable flexible ureterorenoscopes to quantify their greenhouse gas emissions and health impacts within a German hospital setting. The study demonstrated that reusable devices are associated with nearly four times fewer greenhouse gas emissions and lower Disability-Adjusted Life Years per intervention than single-use instruments. These findings underscore that medical device choices can have substantial environmental and health impacts, supporting a shift toward more sustainable healthcare solutions.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Donovan et al. introduced Cost-IS, a tool designed to estimate the costs of implementing digital health solutions. Its development involved a modified e-Delphi process with 12 experts, who reached consensus on its core design and components. However, consensus was lacking regarding the required user knowledge, how specific the tool should be for digital health, and its digital availability. The authors concluded that further testing is needed to establish the tool’s feasibility in real-world settings.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. In a recent publication, Casado-Arroyo et al. assessed the current landscape of health technology assessment (HTA) for innovative cardiology devices in Europe. The review identified three central themes: the expanding role of clinicians in HTA processes, the integration of digital technologies and AI into assessment frameworks, and significant variation in HTA practices across EU countries. The authors noted that new regulatory initiatives, such as the HTA Regulation, could facilitate alignment between clinical practice, evidence-based evaluation, and reimbursement processes.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Sustainability Publications Digest. In a recent publication, Kloevekorn et al. conducted a qualitative systematic review to analyze direct sources of carbon emissions in hospital surgical care, using the Congruence Model as a framework. The authors found that major emission sources include anesthetic gases, sterilization practices, and ingrained workplace behaviors, while sustainability efforts are primarily linked to waste policies. The study highlights the value of the Congruence Model for uncovering challenges in decarbonizing surgical care.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. In a recent publication, Jaksa et al. conducted a targeted review of health technology reassessments across six international HTA agencies to examine the use of real-world evidence (RWE). The analysis of 40 recent reassessments found that 55% incorporated RWE, primarily drawing on registry data to address clinical uncertainties. However, RWE use did not alter patient access outcomes, and no de novo comparative RWE studies were identified, highlighting the need for greater alignment between agencies and sponsors on evidence needs and study feasibility.