Publication Digest: Defining Biological and Clinical Plausibility: The DICSA Framework for Protocolized Assessment in Survival Extrapolations Across Therapeutic Areas

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Publications Digest. 

In a recent publication, Heeg et al. proposed a systematic framework to define biologically and clinically plausible survival extrapolations, addressing inconsistencies in current health technology assessments (HTA). Reviewing 29 international HTA guidelines, the authors introduced the DICSA protocol — a five-step process that integrates evidence synthesis with local clinical context to evaluate survival expectations prior to modeling. This framework aims to standardize and enhance the transparency of survival extrapolations, supporting more consistent decision-making in HTA processes.

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