Health economics

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Thokala et al. provided an overview of how resource constraints can be incorporated into health economic evaluations. Drawing on literature and expert input, the authors identified three distinct categories of resource constraints: single-use resources, reusable resources, and constraints related to patient throughput. They also developed a comprehensive framework to guide a more accurate and realistic assessment of health technologies under real-world limitations. Their findings underscore the importance of systematic consideration of resource constraints by HTA agencies to enhance the relevance of economic evaluations.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Reason et al. introduced how generative artificial intelligence (GenAI), particularly large language models (LLMs) like ChatGPT, can support health economics and outcomes research (HEOR). The authors highlight that LLMs can streamline a range of HEOR activities, including literature summary, data extraction, report drafting, and statistical code generation. However, they also point out key limitations, such as the risk of hallucinated outputs, security vulnerabilities, reproducibility issues, and potential bias. Implementing LLMs in HEOR necessitates robust security measures to ensure compliance with the European Union’s General Data Protection Regulation (GDPR) and the United States’ Health Insurance Portability and Accountability Act (HIPAA) when handling sensitive data.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Fleurence et al. introduced a structured taxonomy of generative AI in health economics and outcomes research (HEOR). The authors explore foundational concepts and map emerging applications across domains such as economic modeling, real-world evidence, and dossier development. Key methodological tools - including prompt engineering, retrieval-augmented generation, domain-specific models, and model fine-tuning - are discussed as means to enhance performance and reliability. While the transformative potential of generative AI in HEOR is recognized, the study highlights ongoing challenges around bias, reproducibility, and practical implementation. The report calls for deeper integration of HEOR expertise into AI development to leverage these technologies in health decision-making responsibly.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Dijk et al. piloted the CHEQUE tool in the context of systematic reviews of health economic studies in medical education, aiming to assess its usability and inform future improvements. The authors applied CHEQUE to 21 economic evaluations, uncovering a wide range in quality scores (18%‒94%) and a positive correlation between methodological rigor and reporting standards. The study highlighted CHEQUE’s value as a structured assessment tool but also pointed to the need for refinements to reduce complexity and enhance clarity.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Kachapila et al. conducted a systematic review to investigate the integration of economic evaluations into multiarm, multistage, adaptive Randomized Controlled Trials. The review included 17 articles, with four reporting results of economic evaluations and 13 presenting economic evaluation protocols. Although costs and benefits could be estimated at interim stages in 14 studies, only five interim cost-effectiveness analyses were performed, and just three influenced decisions to drop or maintain trial arms. Overall, the use of economic evidence remains limited, despite its potential value in guiding adaptive decisions.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Donovan et al. introduced Cost-IS, a novel tool designed to support the economic evaluation of implementation strategies for digital health solutions. Its development followed a structured, multi-phase approach involving a literature review, expert interviews, and a modified e-Delphi process. A panel of 12 multidisciplinary experts reached a consensus on the instrument’s core design, though additional piloting is required to evaluate its real-world feasibility and generalizability.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Mascarenhas et al. analyzed the landscape of economic evaluations for medical devices in pediatrics, critically appraising their methodological rigor. The systematic literature review identified 39 economic evaluations, with a focus on high-risk therapeutic devices mostly studied in high-income countries. The analysis showed a predominant use of cost-utility analysis and considerable variation in adherence to CHEERS 2022 reporting standards. The findings highlight the need to improve reporting quality and develop methods that reflect the unique health needs of children, including outcome measures meaningful to pediatric patients and their families.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Elsner et al. conducted a literature review to evaluate the economic value of cardiovascular implantable electronic devices for heart failure treatment, with a focus on the European context over the past 10 years. The review assessed the economic implications of various device therapies, including cardiac resynchronization therapy with a pacemaker (CRT-P), CRT with a defibrillator (CRT-D), implantable cardioverter-defibrillators (ICDs), pacemakers, and (semi)automated telemonitoring, using QALYs and ICERs as standardized measures of cost-effectiveness. All cardiovascular implantable electronic devices were found to fall within commonly accepted cost-effectiveness thresholds.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Elvidge et al. introduced the CHEERS-AI checklist, a standardized reporting framework for economic evaluations of AI-based health interventions. Developed through a Delphi study with multidisciplinary experts, the checklist comprises 38 reporting items, including AI-specific considerations. By improving transparency and reproducibility, CHEERS-AI aims to enhance the quality of cost-effectiveness assessments and facilitate informed decision-making in AI-driven healthcare.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Larsen et al. explored potential healthcare savings in Denmark associated with the use of artificial intelligence-assisted vital signs monitoring systems. Based on the hypothesis, implementing these systems could potentially reduce the occurrence of serious adverse events in hospitalized patients. Utilizing Danish national registry data, the authors estimated economic benefits from the implementation of AI-assisted monitoring systems, highlighting significant potential savings from decreased length of hospital stay and fewer readmissions. However, the study highlighted the need for a more precise evaluation of the clinical effectiveness of AI-assisted technologies and detailed consideration of associated implementation costs.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, van den Broek-Altenburg et al. reviewed 20–25 years of economic value assessment approaches in healthcare, highlighting the growing focus on individual preferences over broad societal metrics in value-based care models. The study underscores the complexities of incorporating patient-specific preferences into economic evaluations, and addresses recognized limitations of QALY measures. The authors discussed emerging alternative valuation frameworks that could influence future policy and reimbursement decision-making.

MTRC shares the most relevant and impactful publications in the field of market access and HEOR for medical technologies in Europe through its Health Economic Publications Digest. In a recent publication, Donovan et al. conducted a qualitative interview study with 16 experts to investigate the gaps in capturing implementation costs within economic evaluations. The study revealed four key barriers: difficulties in defining, collecting, and valuing implementation costs; the lack of standardized methodologies; and the lack of multidisciplinary collaboration in enabling implementation costing. The authors advocated for standardized approaches to implementation cost estimation, emphasizing that improved methodologies could enhance confidence in economic assessments and better inform resource allocation.